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病理诊断免疫组化 头颈部

2016-09-05 10:44  阅读(927)  评论(0)  分类:专业

第一节 鳞状上皮增生性病变

1.鳞状细胞癌

阳性:PanCKAE1/AE3CK5/6P63CK34βE

阴性:CAM5.2

 

2.基底样鳞状细胞癌

阳性:AE1/AE3EMACEAS-100NSEc-kitP53P63

阴性:CgASyn

 

3.疣状癌和乳头状鳞状细胞癌

阳性:PanCKAE1/AE3CK5/6P63

阴性:CAM5.2

 

4.梭形细胞癌

阳性:CKKeratinSMAMSADesmin

 

第二节 鼻腔和鼻窦病变

1.嗅神经母细胞瘤

阳性:SynNSECgACAM5.2

阴性:EMAS-100CD99MSADesmin

 

2.鼻腔鼻窦未分化癌

阳性:PanCKCK8CK7CK19EMANSEP53CD99SynCgA

阴性:CEAS-100CK4CK5/6CK10CK14

 

3.恶性黑色素瘤

阳性:S-100HMB45Melan-Atyrosinasevimentin

阴性:CAM5.2EMACK

4.神经内分泌癌(小细胞神经内分泌癌)

阳性:CAM5.2AE1/AE3SynCgANSETTF-1CD99CD56

阴性:CK20S-100NF

 

5.髓外浆细胞瘤

阳性:CD38CD138VS38IgGIgAIgLCD79aOCT2BoB1EMA

阴性:IgDIgEIgMCD20

 

6.侵袭性或外生性垂体腺瘤

阳性:SynCgANSE,激素,CAM5.2AE1/AE3

阴性:CK7CK19CK20S-100

 

7.横纹肌肉瘤

阳性:DesminMSAMyogeninMyoD1CD99

阴性:CKS-100

 

8.尤文肉瘤或原始神经外胚叶肿瘤

阳性:PASvimentinCD99SynCgANSEFLI-1Leu7NestinPgp9.5NB-84CAM5.2AE1/AE3

 

9.鼻腔鼻窦型血管周细胞瘤

阳性:F8vimentinSMAMSACD34S-100Bcl-2Laminin

阴性:CD99CD117

 

10.肠型腺癌

阳性:PanCKCDX2MUC2CK20EMACAM5.2

部分阳性:CEACgACK7

 

第三节 鼻咽病变

1.鼻咽癌

阳性:Pan-CKCK5/6CK8CK13CK19P53EBV

阴性:CK7CK4CK10CK14HER2LCAHMB45SynMyogenin

 

2.鼻咽血管纤维瘤

阳性:CD34vimentinSMAβ-cateninARPRER

阴性:CKS-100

 

第四节 口腔及口咽病变

1.颗粒细胞瘤

阳性:S-100NSEα-ACTCD68vimentinINHPgp9.5CalretininCD57

阴性:KeratinMac387SMAMSADesmin

 

第五节 咽喉病变

1.神经内分泌癌谱(典型类癌,非典型类癌,小细胞神经内分泌癌)

阳性:CgASynNSECEAEMACK

阴性:HMB45LCATTF-1

 

第六节 涎腺病变

1.多形性腺瘤

阳性:CKS-100GFAPBcl-2SMAP63

阴性:CgASynNSE

 

2.多形性低度恶性腺癌

阳性:CKvimentinS-100CEAEMA

阴性:GFAP

 

3.腺样囊性癌

阳性:AE1/AE3CK157810141819CK5/6P6334βE12SMAc-kit

 

4.肌上皮瘤

阳性:AE1/AE3CK7CK14S-100P63calponinSMAvimentin

 

5.上皮肌上皮癌

阳性:KeratinS-100P63CalponinHHF35SMA

阴性:CK

 

6.透明细胞癌

阳性:CK903EMACEA

阴性:S-100SMAP63

 

7.唾液腺导管癌

阳性:CKEMACEAAE1/AE3GCDFPARHER2

阴性:S-100P63ERPR

 

第七节 耳颞病变

1.中耳腺瘤

阳性:AE1/AE3CK20CK7CAM5.2CgASyn

 

2.内淋巴管囊瘤

阳性:AE1/AE3CAM5.2vimentinNSES-100GFAP

阴性:thyroglobulinthansthyreti

 

3.异位脑膜瘤

阳性:EMAvimentinS-100

阴性:CKCgASynNSE

 

第八节 副节瘤

副节瘤和恶性副节瘤

阳性:CgASynNSELeu7S-100GFAP

阴性:CKEMA

 

第九节 转移性肿瘤

1.转移性前列腺癌

阳性:PSAPPSAAR

 

2.转移性肾细胞癌

阳性:RCCABCvimentin

 

3.头颈部转移性肺癌

阳性:CK7CK20TTF-1SP-A

 


 

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