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病理诊断免疫组化 头颈部
第一节 鳞状上皮增生性病变
1.鳞状细胞癌
阳性:PanCK,AE1/AE3,CK5/6,P63,CK34βE
阴性:CAM5.2
2.基底样鳞状细胞癌
阳性:AE1/AE3,EMA,CEA,S-100,NSE,c-kit,P53,P63
阴性:CgA,Syn
3.疣状癌和乳头状鳞状细胞癌
阳性:PanCK,AE1/AE3,CK5/6,P63
阴性:CAM5.2
4.梭形细胞癌
阳性:CK,Keratin,SMA,MSA,Desmin
第二节 鼻腔和鼻窦病变
1.嗅神经母细胞瘤
阳性:Syn,NSE,CgA,CAM5.2
阴性:EMA,S-100,CD99,MSA,Desmin
2.鼻腔鼻窦未分化癌
阳性:PanCK,CK8,CK7,CK19,EMA,NSE,P53,CD99,Syn,CgA
阴性:CEA,S-100,CK4,CK5/6,CK10,CK14
3.恶性黑色素瘤
阳性:S-100,HMB45,Melan-A,tyrosinase,vimentin
阴性:CAM5.2,EMA,CK
4.神经内分泌癌(小细胞神经内分泌癌)
阳性:CAM5.2,AE1/AE3,Syn,CgA,NSE,TTF-1,CD99,CD56
阴性:CK20,S-100,NF
5.髓外浆细胞瘤
阳性:CD38,CD138,VS38,IgG,IgA,IgL,CD79a,OCT2,BoB1,EMA
阴性:IgD,IgE,IgM,CD20
6.侵袭性或外生性垂体腺瘤
阳性:Syn,CgA,NSE,激素,CAM5.2,AE1/AE3
阴性:CK7,CK19,CK20,S-100
7.横纹肌肉瘤
阳性:Desmin,MSA,Myogenin,MyoD1,CD99
阴性:CK,S-100
8.尤文肉瘤或原始神经外胚叶肿瘤
阳性:PAS,vimentin,CD99,Syn,CgA,NSE,FLI-1,Leu7,Nestin,Pgp9.5,NB-84,CAM5.2,AE1/AE3
9.鼻腔鼻窦型血管周细胞瘤
阳性:F8,vimentin,SMA,MSA,CD34,S-100,Bcl-2,Laminin
阴性:CD99,CD117
10.肠型腺癌
阳性:PanCK,CDX2,MUC2,CK20,EMA,CAM5.2
部分阳性:CEA,CgA,CK7
第三节 鼻咽病变
1.鼻咽癌
阳性:Pan-CK,CK5/6,CK8,CK13,CK19,P53,EBV
阴性:CK7,CK4,CK10,CK14,HER2,LCA,HMB45,Syn,Myogenin
2.鼻咽血管纤维瘤
阳性:CD34,vimentin,SMA,β-catenin,AR,PR,ER
阴性:CK,S-100
第四节 口腔及口咽病变
1.颗粒细胞瘤
阳性:S-100,NSE,α-ACT,CD68,vimentin,INH,Pgp9.5,Calretinin,CD57
阴性:Keratin,Mac387,SMA,MSA,Desmin
第五节 咽喉病变
1.神经内分泌癌谱(典型类癌,非典型类癌,小细胞神经内分泌癌)
阳性:CgA,Syn,NSE,CEA,EMA,CK
阴性:HMB45,LCA,TTF-1
第六节 涎腺病变
1.多形性腺瘤
阳性:CK,S-100,GFAP,Bcl-2,SMA,P63
阴性:CgA,Syn,NSE
2.多形性低度恶性腺癌
阳性:CK,vimentin,S-100,CEA,EMA
阴性:GFAP
3.腺样囊性癌
阳性:AE1/AE3,CK1,5,7,8,10,14,18,19,CK5/6,P63,34βE12,SMA,c-kit
4.肌上皮瘤
阳性:AE1/AE3,CK7,CK14,S-100,P63,calponin,SMA,vimentin
5.上皮肌上皮癌
阳性:Keratin,S-100,P63,Calponin,HHF35,SMA
阴性:CK
6.透明细胞癌
阳性:CK903,EMA,CEA
阴性:S-100,SMA,P63
7.唾液腺导管癌
阳性:CK,EMA,CEA,AE1/AE3,GCDFP,AR,HER2
阴性:S-100,P63,ER,PR
第七节 耳颞病变
1.中耳腺瘤
阳性:AE1/AE3,CK20,CK7,CAM5.2,CgA,Syn
2.内淋巴管囊瘤
阳性:AE1/AE3,CAM5.2,vimentin,NSE,S-100,GFAP
阴性:thyroglobulin,thansthyreti
3.异位脑膜瘤
阳性:EMA,vimentin,S-100
阴性:CK,CgA,Syn,NSE
第八节 副节瘤
副节瘤和恶性副节瘤
阳性:CgA,Syn,NSE,Leu7,S-100,GFAP
阴性:CK,EMA
第九节 转移性肿瘤
1.转移性前列腺癌
阳性:PSAP,PSA,AR
2.转移性肾细胞癌
阳性:RCC,ABC,vimentin
3.头颈部转移性肺癌
阳性:CK7,CK20,TTF-1,SP-A
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