Lung adenocarcinoma

TTF-1, NapsinA

Breast CA

GATA3, ER, GCDFP-15

Urothelial CA

GATA3,   UPII, S-100P, CK5/6, p63,   CK20

Squamous cell   CA

p40, CK5/6, p63, SOX2

RCC, clear cell   type

PAX8/PAX2, RCCma, pVHL,   KIM-1

Papillary RCC

P504S, RCCma,   pVHL, PAX8, KIM-1

Translocational   RCC

TFE3

HCC

Arginase-1, glypican-3

Adrenal   cortical neoplasm

Mart-1,   inhinbin-alpha, calretinin, SF-1

Melanoma

S-100, Mart-1, HMB45, MiTF, SOX10, PNL2

Merkel cell CA

CK20(perinuclear dot staining), MCPvy

Mesothelial origin

Calretinin, WT-1, D2-40, CK5/6,   mesothelin

Neuroendocrine origin

Chromogranin, synaptophysin, CD56

Upper GI tract

CDH17, CDX2, CK20

Lower GI tract

SATB2, CDX2, CK20, CDH17

Intrahepatic   cholangiocarcinoma

pVHL, CAIX

Pancreas,   acinar cell CA

Glypican-3, antitrypsin, Bcl-10

Pancrease,   ductal ADC

MUC5AC, CK17, maspin, S-100P

Pancrease, NET

PR, PAX8, PDX1,   CDH17, islet-1

Pancrease, SPT

Nuclear beta-catenin, loss of E-cadherin,   PR, CD10, vimentin, chromogranin negative

Prostate, ADC

NKX3.1, PSA, PSAP, ERG

Ovarian Serous   CA

PAX8, ER, WT-1

Ovarian clear   cell CA

pVHL, HNF-1B, KIM-1, PAX8

Endometrial ADC

PAX8/PAX2, ER, vimentin

Endocerivival   ADC

PAX8, p16, CEA, HPV in situ   hybridization, loss of PAX2

Thyroid   follicular cell origin

TTF-1, PAX8,   thyroglobulin

Thyroid   medullary CA

Calcitionin,   TTF-1, CEA

Salivary duct   CA

GATA3, AR,   GCDFP-15, HER2

Thymic origin

PAX8, p63, CD5

Seminoma

SALL4, LIN28, OCT4, CD117, D2-40

Yolk sac tumor

SALL4, LIN28, glypican-3, AFP

Embryonal CA

SALL4, LIN28, OCT4, NANOG, CD30, SOX2

Choriocarcinoma

GATA3, Beta-HCG, CD10

Sex cord   stromal tumors

SF-1, inhibin-alpha, calretinin, FOXL2

Vascular tumor

ERG, CD31, CD34, Fli1

Synovial   sarcoma

TLE1,   cytokeratin

Chordoma

Cytokeratin,   S-100

Desmoplastic small round cell tumor

Cytokeratin,   CD99, desmin, WT-1(N-terminus)

Alveolar soft   part sarcoma

TFE3

Rhabdomyosarcoma

Myogenin,   desmin, MyoD1

Smooth muscle   tumor

SMA, MSA,   desmin, calponin

Ewing   sarcoma/PNET

NKX2.2, CD99, Fli-1

Myxoid and round cell liposarcoma

NY-ESO-1

Low-grade   fibromyxoid sarcoma

MUC4

Epithelioid   sarcoma

CD34, loss of INI1

Atypical   lipomatous tumor

MDM2(MDM2 by FISH is a more sensitive and   spectific test), CDK4

Histiocytosis X

CD1a, S-100, Langerin(CD207)

Angiomyolipoma

HMB45, SMA

Gastrointestinal   stromal tumor

CD117, DOG1

Solitary   fibrous tumor

STAT6, CD34, Bcl-2, CD99

Myoepithelial   CA

Cytokeratin and myoepithelial markers(may   lose INI1)

Myeloid sarcoma

CD43, CD34, MPO

Follicular   dendrtic cell tumor

CD21, CD35

Mast cell tumor

CD117, tryptase