张学敏：男，研究员（教授），细胞生物学博士生导师，1963年11月出生，

张学敏

江西泰和人。现任军事医学科学院仪器测试分析中心（国家大型科学仪器中心）主任，国家生物医学分析中心主任。国家973项目首席科学家。主持建立了大型生物质谱技术平台，是我国最有影响力和发挥作用最广泛的质谱技术平台之一，并以此为依托主持国家"863"、国家"973"、 国家科技平台建设项目、国家自然科学基金等重要科研任务。在SCI收录杂志包括Nature Immunology、The EMBO J、Molecular and Cellular Proteomics、J Biol Chem、Oncogene等发表论文36篇，其中署名通讯作者25篇，主要发现和结论被国际权威杂志多次重点介绍和评述。2005年获国家杰出青年科学基金；2005年获得军队优秀专业技术人才岗位津贴(一类)； 2007年入选新世纪百千万人才工程国家级人选；2008年获得国家自然科学二等奖（署名第1）。

2011年当选中国科学院院士。

2012年当选为中国共产党第十八次全国代表大会代表^[1]

2主要学历编辑

1997.6—1998.8 美国Wayne State大学免疫学，博士后

1992.8—1995.8 军事医学科学院基础医学研究所分子生物学，博士

1986.8—1989.8 军事医学科学院基础医学研究所分子生物学，硕士

1981.8—1986.8 第三军医大学临床医学系，学士

3近5年发表主要学术论文编辑

1. Pei-Jing Zhang, Wei-Hua Li, Jie Zhao, Xin Pan, Tao Zhou, Wei-Li Gong, Ai-Ling Li and Xue-Min Zhang (通讯作者). Deactivation of IKK by CUE domain containing 2 (CUEDC2) via r Hui-Yan Li, Hui Liu, Chen-Hui Wang, Ji-Yan Zhang, Jiang-Hong Man, Yan-Fei Gao, ecruitment of the protein phosphatase PP1。Nature Immunology,9:533-541; 2008.

2. Zhang, P.J., Zhao, J., Li, H.Y., Man, J.H., He, K, Zhou, T., Pan, X., Li, A.L., Gong, W.L., Jin, B.F., Xia, Q., Yu, M., Shen, B.F., Zhang, X.M (通讯作者). CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin proteasome. The EMBO Journal, 2007, Vol.26, 1831-1842

3. Jiu-wei Cui, Wei-hua Li, Jie Wang, Ai-ling Li, Hui-yan Li, Hong-xia Wang, Kun He, Wei Li, Li-hua Kang, Ming Yu, Bei-fen Shen, Guan-Jun Wang, and Xue-min Zhang (通讯作者). Proteomics-based Identification of Human Acute Leukemia Antigens That Induce Humoral Immune Response. Molecular and Cellular Proteomics, 2005, 4:1718-1724.

Jiang-Hong Man, Hui-Yan Li1, Pei-Jing Zhang, Tao Zhou, Kun He, Xin Pan, Bing Liang, Ai-Ling Li, Jie Zhao, Wei-Li Gong, Bao-Feng Jin, Qing Xia, Ming Yu, Bei-Fen Shen and Xue-Min Zhang.(通讯作者). PIAS3 induction of PRB sumoylation represses PRB

4. transactivation by destabilizing its retention in the nucleus. Nuclear Acid Research, 2006, Vol. 34, No. 19 5552-5566..

5. Bao-Feng Jin, Kun He, Hong-Xia Wang, Bing Bai, Tao Zhou, Hui-Yan Li, Jiang-Hong Man, Bing-Yu Liu, Wei-Li Gong, Jie Wang, Ai-Ling Li, and Xue-Min Zhang (通讯作者). Proteomics analysis reveals insight into the mechanism of H-Ras-mediated transformation. Journal of Proteome Research, 2006, 5 : 2815 -2823.

6. T Zhou, B Liang , GY Su, WL Gong, HY Li, LF Tian, K He, J Zhao, JH Man, T Li, WH Li, ZY Zhang, CH Wang, AL Li, H Liu, X Pan, PJ Zhang, BF Jin, and XM Zhang(通讯作者). Identification of Ubiquitin Target Proteins Using Cell-Based Arrays.Journal of Proteome Research, 2007, 6 : 4397 -4406

7. Cui JW, Wang J, He K, Jin BF, Wang HX , Li W, Kang LH, Hu MR, Li HY, Yu M, Shen BF, Wang GJ, Zhang XM(通讯作者). Proteomics analysis of human acute leukemia cells: insight into their classifications. Clinical Cancer Research, 2004 Oct 15; 10(20):6887-96.

8. Li AL, Li HY, Jin BF, Ye QN, Zhou T, Yu XD, Pan X, Man JH, He K, Yu M, Hu MR, Wang J, Yang SC, Shen BF, Zhang XM(通讯作者). A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. Journal of Biological Chemistry，2004 Nov 19; 279(47):49251-8.

9. Jin BF, He K, Wang HX, Wang J, Zhou T, Lan Y, Hu MR, Wei KH, Yang SC, Shen BF, Zhang XM.(通讯作者). Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A. Oncogene，2003 22:4819-4830.

10. Wei-Hua Li, Jie Zhao, Hui-Yan Li, Hui Liu, Ai-Ling Li, Hong-Xia Wang, Jie Wang, Kun He, Bing Liang, Ming Yu, Bei-Fen Shen, and Xue-Min Zhang(通讯作者). Proteomics-based identification of autoantibodies in the sera of healthy Chinese individuals from Beijing. Proteomics2006 6: 4781-9

11. Cui JW, Wang J, He K, Jin BF, Wang HX , Li W, Kang LH, Hu MR, Li HY, Yu M, Shen BF, Wang GJ, Zhang XM (通讯作者). Two-dimensional electrophoresis protein profiling as an analytical tool for human acute leukemia classification. Electrophoresis，2004 Dec 29;26(1):268-279.

12. Tian LF, Li HY, Jin BF, Pan X, Man JH, Zhang PJ, Li WH, Liang B, Liu H, Zhao J, Gong WL, Zhou T, Zhang XM(通讯作者). MDM2 interacts with and downregulates a sarcomeric protein, TCAP. Biochem Biophys Res Commun.2006 Jun 23;345(1):355-61.

13. Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X(通讯作者).Ubc9 interacts with SOX4 and represses its transcriptional activity Biochem Biophys Res Commun.2006 Jun 9; 344(3):727-34.