ISS分期标准（新国际标准）：
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I期          血清β2－MG<3.5mg/L          中位OS：62个月

II期          1期和3期之间                        中位OS：44个月

III期         血清β2－MG≥5.5mg/L          中位OS：29个月
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D-S分期系统：
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分期                                               特征
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I期                                                  符合下列各项：
低肿瘤负荷                                       血红蛋白 > 10 g/dL
(< 0.6 × 1012 个细胞/m2)                M蛋白合成率低
                                                       IgG < 5 g/dL
                                                         IgA < 3 g/dL
                                                        尿κ或λ轻链< 4 g/24 小时
                                                       血钙正常
                                                        骨骼结构正常或仅有一处溶骨性病变

II期                                                 介于I期和III期之间
中等肿瘤负荷
(0.6–1.2 ×1012个细胞/m2)

III期                                                符合下列至少任何一项：
高肿瘤负荷                                       血红蛋白 < 8.5 g/dL
(> 1.2 × 1012个细胞/m2)                  M蛋白合成率高
                                                        IgG > 7 g/dL
                                                        IgA > 5 g/dL
                                                        尿κ或λ轻链> 12 g/24 小时
                                                        血钙 > 12.0 mg/dL
                                                        溶骨性病变多于3处
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亚型   A：肾功能正常（肌酐< 2.0 mg/dL） B：肾功能损害（肌酐 ≥2.0 mg/dL）