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胃肠道间质肿瘤恶性程度评估标准--文献报道
原发GISTs的分级,Fletcher等标准
肿瘤的恶性潜能        肿瘤最大直径(cm)        有丝分裂计数(/50HPFs)     
极低                           <2                            <5                                                                
低度                          2~5                             <5                       
中度                           <5                             6~10    
                               5~10                            <5           
高度                           <5                              >5                      
                                >10                          任意核分裂像   
                              任意大小                         >10       
                   
Proposed Guidelines for the Evaluation of GIST Malignancy(from Miettinen et al., Hum Pathol 33:478-483, 2002)
Stomach Intestine
Probably benign             ≤5 cm and                   ≤2 cm and
                       <5 mitoses/50 HPFs             <5 mitoses/50 HPFs  
Probably malignant         >10 cm or                     >5 cm or
                       >5 mitoses/50 HPFs              >5 mitoses/50 HPFs
Uncertain or low          >5 cm but ≤10 cm and      >2 cm but ≤5 cm and
Malignant potential     <5 mitoses/50 HPFs             <5 mitoses/50 HPFs
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