There are diffuse infiltrating epithelioid cells in the lamina propria. The cell borders are not clear.  Some cells have clear cell changes (胞浆中有空泡),  间质内有少量的出血，结合病史要除外肾细胞癌.

Other common entities in the differential diagnosis include:

低分化腺癌(胃印戒细胞癌), 间叶源性肿瘤, 恶黑, 淋巴瘤, Histocytic lesions

Based on the morphological impression, a panel of immunostains was performed:

CK (focally, weakly +)

EMA (--)

Vimentin(focally +)

S-100(strongly ++)

CD45(--)

CD68(--).

Subsequently, HMB45 was  performed:

HMB45 (++).

When I called to the clinician for the pathology results, he then stated that the patient also had a “mole” removed two years ago, but he did not have a pathology report of the “mole”.

Based on all the above information, it is most consistent with a metastatic melanoma (恶黑).