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推荐:​Neoplastic Lesions of the Skin 2014

2014-08-01 00:26  阅读(204)  评论(0)  分类:皮肤病理

推荐:Neoplastic Lesions of the Skin英文原版高清pdf】纸质版2013年10月30日328页。电子版2014,出版社:Demos Medical Publishing, LLC. 正文362页,完整书签,查找方便,可全文检索。全书共6章,书末附有参考文献和索引。

Chapter 1: Epithelial/Epidermal Lesions

Chapter 2: Adnexal Neoplasms

Chapter 3: Cutaneous Cysts

Chapter 4: Connective Tissue Tumors

Chapter 5: Pigmented Lesions of the Skin

Chapter 6: Cutaneous Lymphoproliferative Disorders

本书特点:文字内容摘要式,条理清楚,重点突出,简明扼要,兼有图谱性质。

举例:Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive cutaneous tumor with low

to intermediate grade malignant potential. It has predilection for the trunk and proximal

extremities of young and middle-aged adults, with slight male predominance. DFSP presents

as a slow-growing, solitary or multiple, polypoid nodular lesion that ranges in size from

0.5 cm to 10 cm. Local recurrence is common (depending on the type of surgery used) and the

risk of metastases is rare (<0.5% of cases, usually to the lungs). Usually, metastatic disease is

preceded by multiple local recurrences and appears to be associated with fibrosarcomatous

transformation. The fibrosarcomatous variant can be seen in 10% to 15% of cases. It is

more aggressive, locally recurs in up to 75% of cases, particularly in acral lesions, and the

rate of metastasis can be seen in up to 20% of cases. DFSP is characterized by a reciprocal

translocation, t(17;22)(q22;q13) (COL1A1and PDGFBgenes) (223–227).

PATHOLOGy (FIGuRE 4-28A–E)

DFSP is a dermal neoplasm that almost always extends into the subcutis (the subcutis is

infiltrated in a lace-like pattern).

The tumor is composed of fairly uniform spindled cells with elongated nuclei showing

little or no pleomorphism and minimal pale cytoplasm.

The cells spindle cells are arranged in a storiform or cartwheel pattern (sometimes

centered on blood vessels).

In contrast with dermatofibroma, there are usually only small amounts of intermingled

collagen.

Thin-walled capillaries


 

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